Brydson made his professional debut in 1926 for Eddie Livingstone's Chicago Cardinals.

The NHL did not recognize the signing of Brydson by Chicago and awarded his pro-rights to Stratford of the Can-Pro League.

The following season, 1929–30, Brydson made his NHL debut, playing in 14 games for the Maple Leafs.

Brydson was also an accomplished golfer and after ending his hockey career went on to enjoy many successes as a professional, highlighted by winning the Canadian PGA Championship in 1944 and 1948.

In recognition of his achievements, he was inducted into the Canadian Golf Hall of Fame in 1982.