It was Iowa's third straight win over the Gophers and the first time that Minnesota had been defeated three years in a row by a single opponent.

The following year in 1921, Iowa faced Notre Dame, coached by Knute Rockne, in the second game of the season.

Duke Slater missed a rare block, and Locke was met by Notre Dame lineman Hunk Anderson.

He carried the ball 37 times and gained a school-record 202 yards rushing in a 14–2 victory over Illinois.

Aubrey Devine, his brother Glenn, Lester Belding, and Duke Slater all graduated after the 1921 season.

Locke returned to the defending Big Ten champions and was named the team captain of the 1922 Hawkeyes squad.

The Hawkeyes defeated the Bulldogs, 6–0, on a touchdown run by Leland Parkin, who succeeded Devine at quarterback.

So significant and important was the game that the Sunday Chicago Tribune bannered the front page of its general news sections with "IOWA ELEVEN SMASHES YALE.

In Locke's final collegiate game against Northwestern, he scored four touchdowns for the third time in his career, leading Iowa to a 37–3 victory.

Locke was also an accomplished student, earning the Big Ten Medal for scholastic and athletic achievement his senior year.

Locke served as an assistant football coach at Iowa briefly, then moved on to Cleveland, where he was associated with a prominent law firm.