Ultimately Lark and Brubaker moved on to other projects, and, after three years of publication, the series ended amid the Infinite Crisis aftermath.

[5] Despite the sales, writer Greg Rucka assured that DC would have continued publishing Gotham Central as long as he wanted to write it and that it was his decision to conclude the series.

Main characters among the ranks of the detectives were Marcus Driver, Romy Chandler, Renee Montoya, Crispus Allen and Josephine "Josie Mac" MacDonald.

Their superiors, Commissioner Michael Akins, Captain Margaret "Maggie" Sawyer and Lieutenant Ron Probson also appeared prominently.

The supporting cast was mainly pulled from the large roster of the Gotham City Police Department and some characters were subjects of their own story arcs.

In August 2006, Brubaker said that he was told that many people at Warner Bros. loved the comic, and that if they had not had a moratorium on Batman television shows, they "could have set up Gotham Central at WB in a heartbeat".