The Gotse Delchev Hollow is characterized by a continental climate; rainfall occurs mainly during spring and autumn, and summers are hot and dry.

In the 1480s, a large domed mosque and Islamic school were founded in Nevrokop by Mehmed Bey, son of Karadja Pasha.

Hadji Kalfa mentioned Nevrokop as a judicial center and noted the presence of mines around the town, with rich deposits of iron ore.

He describes the city as being large, with many mosques, twelve minarets, tekkes for dervishes, inns, hammams, schools, and many beautiful houses and residences of numerous provincial administrations.

Among famous artists born in the city are Rana Mustafa Efendi Nakshbendi – in service to Muhammad Ali of Egypt.

In the 19th century, along with agriculture, husbandry, and beekeeping, the town of Gotse Delchev developed coppersmithing and goldsmithing crafts, packsaddle manufacturing, homespun, leather, and timber trades.

Since the second half of the 19th century, every year in August the Nevrokop Fair was held, which attracted merchants from the Ottoman Empire, Austria-Hungary, France, and other countries.

In 1808–1811, the Christian community in the town built a small church dedicated to the Archangels Michael and Gabriel.

The Bulgarian communities in Plovdiv and Pazardzhik had a positive impact on the cultural revival of Nevrokop: they assisted with teachers, teaching materials, books, and money.

The inclusion of the area within the Kingdom of Bulgaria led to a mass exodus of Muslims from the town and to a lesser extent, from the villages.

In their place settled Bulgarian refugees from the regions of Serres and Drama, whose homelands fell under the rule of Greece.

In 1922, forces of the Macedonian Federative Organization with the support of the Bulgarian government attacked the IMRO local detachments.

In the years of the Bulgarian resistance movement during World War II, a formation led by Aneshti Uzunov operated in the region.

In the following years, agriculture remained the main source of income due to the fertility of arable land and the favorable climate in the Gotse Delchev hollow.

Plants for FM radio transmitters, parts for tower cranes, plastic goods, zippers, and clothing were also built.

[7] The road system of the region suffered from lack of repair, and improvement and transportation became long and expensive.

Distances from Blagoevgrad and Sofia and the difficult roads in the winter led to further isolation of Gotse Delchev.

The town lost its previous importance and even the seat of the Nevrokop Metropolitan Orthodox bishop was transferred to Blagoevgrad.

After the change of political system in 1989, the restitution of property, and the privatization of state-owned industries, the economy of Gotse Delchev became reshaped, especially in the area of agriculture.

After the opening of a new border crossing point between Gotse Delchev and Drama, Greece in 2005, the town gained new importance.

The municipality has been isolated from big industrial centers in Bulgaria due to its geographic location near the closed border with Greece for about sixty years, and the lack of natural resources, the long distances between Gotse Delchev and other bigger towns, and the narrow and poorly maintained roads have contributed to this as well.

After the opening of the Ilinden–Exochi border crossing and improvement of the road system in the area, the economy of the municipality has changed.

The Mediterranean influence in the wide valley of the Mesta river is favorable for modern and productive agriculture.

People also grow wheat, maize for grain, beans, sunflowers, potatoes, tomatoes, peppers, apples, grapes, strawberries, raspberries, blackberries, and other fruits.

Multiple cellphone operators cover the town; there are also landline telephones, internet, and cable TV.

In 2001, the Union of Evangelical Free Church Congregations in Germany opened a private hospital, "Symbol of Hope," for endocrine diseases, with the intention to provide affordable health services for poor people.

The town had been a diocesan seat of the Nevrokop Orthodox diocese, but this has been moved to Blagoevgrad, without changing the name.

Gotse Delchev is near the ruins of the Roman town of Nicopolis ad Nestum and not far from the village of Kovachevitsa, a famous architectural reservation.

PFC Pirin Gotse Delchev is soccer team that plays in the Bulgarian football league.