In 1814 he received the degree of doctor in philosophy from Halle; in 1816 he moved to the Friedrich Wilhelm University, Berlin, where he became licentiate in theology, and qualified as Privatdozent.
From Bonn, where he had JCW Augusti (1772–1841), JKL Gieseler, and Karl Immanuel Nitzsch for colleagues,[2] he was called in 1827 to Göttingen to succeed KF Staudlin (1761-1826).
In that year he helped to found the Theologische Studien und Kritiken, the chief organ of the "mediation" theology (Vermittelungstheologie).
[4] Lücke, who was one of the most learned, multilateral and influential of the so-called "mediation" school of evangelical theologians (Vermittelungstheologie), is now chiefly known by his Commentar über die Schriften des Evangelisten Johannes (4 vols., 1820–1832).
[6] He also published a Synopsis evangeliorum Matthaei, Marci et Lucae cum parallelis Joannis pericopis, jointly with W. M. L. de Wette (1818).