The 1883 predecessor had been assembled shortly after the decision of the North-West Territories Lieutenant-Governor Edgar Dewdney to relocate the capital from Battleford.

Local contractor William Henderson was awarded the project and construction began on the new residence in the spring of 1889 on fifty-three acres.

It boasted running water, which was pumped from a well in the basement to a collection tank situated in the attic, and then fed by gravity throughout the house.

[4] From its completion in 1891 until the formation of the provinces of Alberta and Saskatchewan in 1905, Government House was the workplace and residence of Lieutenant-Governors of the North-West Territories, the legislative buildings being east on Dewdney Avenue.

In 1901 the Duke and Duchess of York, later King George V and Queen Mary – visited the North-West Territories and were accommodated at Regina's Government House, where they received and met local citizens.

Vice-regal residences were something of an anomaly in the political climate and difficult economic situation of the Great Depression and World War II throughout Canada but particularly on the prairies.

He established a small office in the Hotel Saskatchewan on Victoria Avenue downtown, which the Canadian Pacific Railway opened in 1927.

In 1958, renamed Saskatchewan House, the building entered into 10 years' use as an adult education centre until it was proposed that it be demolished and the site redeveloped.

From 1967 John Coulter's play "The Trial of Louis Riel" was performed throughout the summers in the Government House (then "Saskatchewan House") ballroom, arrayed as in photos of the original Supreme Court of the North-West Territories courthouse at the corner of Victoria Avenue and Hamilton Street, Regina, with members of the audience recruited as jurymen.

The period after World War Two saw the demolition of many historic buildings in Regina, such as the old city hall on 11th Avenue, several downtown movie theatres and both Knox United and Trinity Evangelical Lutheran churches.

The grounds that remained, after alienation of a substantial proportion of them for the Pioneer Village old peoples' home built in 1967, were restored to their Edwardian configuration as a provincial centennial project.

The Government House Historical Society holds a Victorian tea in the ballroom on some weekends during the spring, summer and fall season.

Doors have been said to open and close repeatedly with no one near, the sound of crying babies and laughing children have been heard late at night with no one around, and others have claimed to see eerie faces next to theirs when looking into mirrors.