Among his guests were American explorer Daniel Boone, who was in East Florida to inquire about land purchases,[2] and Patrick Tonyn, who was appointed as Grant's successor.

General Nathanael Greene visited Government House in 1784,[3] hosted for an elaborate seven-course meal by Governor Vicente Manuel de Zéspedes.

In 1833–34 Government House was rebuilt with federal funds, following plans drawn up by architect Robert Mills, later famous for designing the Washington Monument.

In 1937, Government House was once again renovated by Jacksonville architect Mellen Clark Greeley as a Works Progress Administration (WPA) project.

During their tour of St. Augustine on April 1, 2001, King Juan Carlos and Queen Sofía of Spain made a public appearance on the east balcony of Government House.

Information about how houses were constructed historically, how they were furnished, who lived in them, and the daily work and recreation in colonial times were all subjects of research for the HSAPB staff.

[11] In 1870, a man by the name of John L. Wilson began negotiations with the government in order to operate a free public library in two rooms of the U.S. Customs House.

After twenty-one years, the library eventually moved to a larger space in 1895 at the Wilson's new property located at 12 Aviles Street, St. Augustine, Florida (known as the Segui-Kirby Smith House).