Government Street Presbyterian reflects the influences of Ithiel Town, Minard Lafever, and Andrew Jackson Downing.

Local millionaire and church trustee, Henry Hitchcock, ran an ad in the Mobile Daily Register in December 1835 that advertised for builders.

[3] A hurricane in 1916 caused $2500 in unspecified damages, and it was decided at that time to further enlarge the rear portion of the church.

The influence of the Town and Davis school on Gallier and the Dakins is evident in the exterior design, with Government Street Presbyterian being extremely similar to Town and Davis' Washington Street Methodist Episcopal Church, completed in 1832 in Brooklyn, New York.

The front elevation features one of the earliest surviving American examples of a distyle in antis portico.

[3][5] The interior is notable for the fact that the original Greek Revival design is fully intact with very little alteration.

The gallery balcony features a Greek key molding topped with rosettes and appears, as does most of the interior, to be based on a design from Minard Lafever's Beauties of Modern Architecture.

Behind the altar is a pylon-like screen with an engaged Corinthian tetrasyle topped by ante-fixae, similar in design to the Choragic Monument of Lysicrates.

The committee selected the European builder Rieger-Kloss of Krnov, Czech Republic to build a new instrument capable of leading congregational and chorale singing, and recital and performance of any literature written for organ.

The result is a 62-rank instrument over six divisions: great, swell, positiv, grand choir, en chamade, and pedal.

Controlled by a four-manual and pedal detached English console, the organ was designed to match the architectural and aesthetic properties of the sanctuary.

The church has worship services, Christian education, music and fine arts, and urban ministries.