Goyder Highway (B64) is a west–east link through the Mid North region of South Australia connecting Spencer Gulf to the Riverland.

It is part of the most direct road route from Port Augusta (and areas beyond including Eyre Peninsula, Western Australia and the Northern Territory) to much of Victoria and southern New South Wales.

Goyder's Line is near the highway from Crystal Brook to past Burra.

[3] The highway descends from the Mount Lofty Ranges onto the plains of the Murray–Darling basin.

It passes the end of Thiele Highway at Morgan and continues upstream on the north side of the Murray River to meet Sturt Highway between Barmera and Monash.