Derangère was born in Montpellier where his parents finished their medicine studies.

[1] He studied acting at the Cours Florent when he was 21 years old in Paris and at École nationale supérieure des arts et techniques du théâtre in Lyon.

[2] At 25, he acted in his first film, Éric Rochant's Anna Oz, with Charlotte Gainsbourg and Gérard Lanvin.

In 2002, he was nominated for a César Award for Most Promising Actor for playing a soldier in François Dupeyron's The Officers' Ward with Sabine Azéma, Éric Caravaca and André Dussollier.

[1] In 2004, he won the César Award for Most Promising Actor for his performance as Frédéric Auger in Jean-Paul Rappeneau's Bon Voyage.