She studied Modern Languages at Jesus College, Cambridge, where she met founding band members Jack Patterson and Neil Amin-Smith, with whom she played in a string quartet.

[3] In January 2014, they scored their first UK chart topping single with "Rather Be", a collaboration with Jess Glynne, featuring elements of both classical and dance music.

[8] Chatto and Jack Patterson formed their own film production company, Cleanfilm, to make music videos for themselves and other artists.

Chatto, with her father, formed a band of singing cellists called the Massive Violins, with whom she still performs.

On 13 November 2020, Chatto was featured on "Stop Crying Your Heart Out" as part of the BBC Radio 2's Allstars' Children in Need charity single.