The hospital is part of LifeBridge Health, a nonprofit healthcare corporation that was formed in 1998 and currently operates several medical institutions in and around Baltimore, Maryland.

Members of the group came to Baltimore from Paris in the 1870s, and they bought the former Maryland Square, a mansion built in 1795 and owned by the Steuart family, which had previously been confiscated for use as a military hospital during the Civil War.

In 1919, George Jenkins, a philanthropist, provided funds to open a Roman Catholic hospital,[2] which was built on the grounds of Maryland Square.

[8] Less than six months after the merger with Mercy, LifeBridge Health announced plans to acquire Baltimore's Bon Secours Hospital.

On December 17, 2019, the hospital changed its name to Grace Medical Center, ending one hundred years of association with the Sisters of Bon Secours.