Graham Cave is a Native American archeological site near Mineola, Missouri in Montgomery County in the hills above the Loutre River.

Extending about 100 feet (30 m) into the hillside, the cave protects an historically important Pre-Columbian archaeological site from the ancient Dalton and Archaic period dating back to as early as 10,000 years ago.

Graham Cave was formed at the point of contact of Jefferson City dolomite and St. Peter sandstone.

After his death, his collection of artifacts was offered by his son Benjamin to the University of Missouri, which investigated the cave in 1930.

Benjamin's son-in-law was persuaded to delay plans to enlarge the shelter for his livestock in 1948 so that archeological excavations could be made.