Grammer, having trained as an actor at Juilliard and the Old Globe Theatre, made his professional acting debut as Lennox in the 1981 Broadway revival of Macbeth.

[3] In mid-1983, he acted alongside Mandy Patinkin in the original off-Broadway production of Stephen Sondheim's musical Sunday in the Park with George.

He has since starred in the leading roles in productions of both Sweeney Todd: The Demon Barber of Fleet Street and My Fair Lady.

[15] After leaving Juilliard, Grammer had a three-year internship with the Old Globe Theatre in San Diego in the late 1970s before a stint in 1980 at the Guthrie Theater in Minneapolis.

He made his Broadway debut in 1981 as "Lennox" in Macbeth, taking the lead role when Philip Anglim withdrew after receiving negative reviews.

Grammer then played Michael Cassio in the 1982 Broadway revival of Othello, alongside James Earl Jones and Christopher Plummer.

From April to June 1992, he played the title role in Richard II, staged at the Mark Taper Forum at the Los Angeles Music Center.

In the show, Frasier has moved from Boston to Seattle and works as a radio psychiatrist alongside his producer Roz (Peri Gilpin).

In addition to starring, Grammer also directed more than 30 episodes, and sang the closing theme "Tossed Salads and Scrambled Eggs".

[19] Grammer himself received 10 Primetime Emmy Award nominations for his role in Frasier, winning four times, tying him with Carroll O'Connor, Michael J.

Commander Thomas "Tom" Dodge in the film Down Periscope (1996), and voiced Vladimir "Vlad" Vasilovich in the 20th Century Fox's critically acclaimed animated movie Anastasia (1997).

In 1999, Grammer voiced the main antagonist Stinky Pete in Pixar's Golden Globe Award-winning Toy Story 2 (1999).

The main cast consisted of Malcolm Barrett, Kaitlin Olson, Mary Lynn Rajskub and Paul F. Tompkins, as well as Lee Mack from the British version of the show.

Grammer starred alongside Douglas Hodge for which they both were nominated for Tony Awards for Best Performance by a Leading Actor in a Musical.

[26] From 2010 to 2012, Grammer guest starred as a comical version of himself in three episodes of the NBC show 30 Rock alongside Jane Krakowski and Jack McBrayer.

Later that same year, Grammer starred in several films such as Bonaparte in The Expendables 3 (2014) and as Harold Attinger in Transformers: Age of Extinction (2014).

In 2015 Grammer and John Lithgow lent their voices to the critically acclaimed documentary Best of Enemies as William F. Buckley Jr. and Gore Vidal, respectively.

[27] The documentary surrounds the events around the televised debates between intellectuals Vidal and Buckley during the 1968 United States presidential election.

That same year he starred as Harry Hamilton in the Netflix film Like Father (2018), alongside Kristen Bell, and as a detective opposite Nicolas Cage in Grand Isle (2019).

[49] The couple announced their engagement in December 2010[50] and married at the Plaza Hotel in New York City on February 25, 2011, two weeks after the dissolution of Grammer's third marriage.

According to Grammer, his bouts of alcoholism and drug abuse were driven, in part, by guilt and depression over his sister's death, as the pair had been close in childhood.

[78] In August 1990, Grammer was charged again with cocaine possession and was sentenced to three years' probation, fined $500, and required to perform 300 hours of community service.

[78] In September 1996, he crashed his Dodge Viper sports car while intoxicated, and subsequently checked into the Betty Ford Center for 30 days.

The cast and producers of both Frasier and Cheers held interventions to help him; co-star Bebe Neuwirth and writer Ken Levine cited delays with rehearsals and filming due to his erratic behavior.

"[84] In 1988, Grammer was arrested for possession of one-quarter gram of cocaine, after being pulled over in a traffic stop for driving with expired plates in North Hollywood, California.

Later in the same year, Grammer was sentenced to 90 days of house arrest, ordered to pay a $500 fine, underwent drug and alcohol abuse counseling, and performed 300 hours of community service for his 1988 cocaine possession case.

A grand jury chose not to indict the actor, stating: "The young woman's delay of more than a year in pressing charges against Mr. Grammer made it difficult to support her claim."

He was the first American actor to be nominated for multiple Emmy awards for portraying the same character on three different television shows (Cheers, Frasier, and Wings).

In 2010, Grammer received his first Tony Award nomination for Best Actor in a Musical for his performance in La Cage Aux Folles opposite Douglas Hodge.

He received a nomination from the Directors Guild of America Award in 1999, for directing the Frasier episode "Merry Christmas, Mrs. Moskowitz".