The 53rd Annual Grammy Awards were held on February 13, 2011, at the Staples Center in Los Angeles.

Barbra Streisand was honored as the MusiCares Person of the Year two nights prior to the telecast on February 11.

Arcade Fire won Album of the Year for The Suburbs becoming the first indie act to do so,[3] and surprising many viewers and critics.

Other multiple winners include: David Frost, John Legend, Lady Gaga, Jay-Z, and Jeff Beck with three awards each.

James Moody, John D. Kendall, Billy Taylor, Herb Ellis, Lena Horne, Margaret Whiting, Charlie Louvin, Hank Cochran, Carl Smith, Bobby Charles, Bobby Hebb, Gladys Horton, Teena Marie, General Johnson, Gregory Isaacs, Sugar Minott, Harvey Fuqua, Garry Shider, Dick Griffey, Gerry Rafferty, George David Weiss, Wally Traugott, Jim Williamson, Bill Porter, Richie Hayward, Ben Keith, Captain Beefheart, Malcolm McLaren, Herman Leonard, Irwin Silber, Jim Marshall, Jerry Bock, Allyn Ferguson, John Barry, Peter Lopez, Caresse Henry, Bill Aucoin, Hal Uplinger, Ron Baird, Ronni Chasen, Mitch Miller, Roberto Cantoral, Olga Guillot, Enrique Morente, Joan Sutherland, Helen Boatwright, Margaret Price, Earl Wild, Raphael Hillyer, Ronnie James Dio, Doug Fieger, Don Kirshner, Esteban "Steve" Jordan, Tony "Ham" Guerrero, Eddie Fisher, Jimmy Dean, Alex Chilton, Walter Hawkins, Albertina Walker and Solomon Burke.