The tenth season of the Argentine version of the television reality show Gran Hermano was announced on 21 June 2022 by Telefe.

[3] Each week, the HouseGuests compete in a Head of Household (HoH) competition which gives them immunity from nominations and the power to save one of the nominees up for eviction.

[6][7] Marcos Ginocchio was crowned the winner of the season, with Juan Ignacio Castañares finishing as runner-up and Julieta Poggio in third place.

[9] The show follows a group of contestants, known as HouseGuests, who live inside a custom-built house outfitted with cameras and microphones recording their every move 24 hours a day.

[4] With over 2,500 square metres, it would become the biggest house ever of Gran Hermano Argentina, including 1,200 m2 indoors, 400 m2 outdoors, a supermarket, and the "arena" in which the HouseGuests are expected to compete for games and challenges.

[69] The season aired from Sundays through Fridays on Telefe, with nomination galas on Wednesdays, eviction galas on Sundays, debates on Mondays, Tuesdays and Thursdays, and a special edition called Night with the Exes (La Noche de los Ex in Spanish) with former HouseGuests from previous seasons on Fridays.

The debates are joined by panelists Sol Pérez, Nati Jota, Laura Ubfal, Gastón Trezeguet, Ceferino Reato, Cristian Urrizaga and Analía Franchín, while the Night of the Exs being hosted by Roberto Funes Ugarte.

[71] Telefe aired in simulcast the season via YouTube and Twitch, hosted by Vicky "Juariu" Braier and Diego Poggi.

[72] The premiere of the tenth season the YouTube broadcasting reached 49,000 live users, while on Twitch the stream gained over 31,500 viewers.