Gran Hermano 11 launched on September 6, 2009, with the final on January 27, 2010, lasting 144 days, making it the longest season to date.

Mercedes Milá returned as the main host of the show, also known as the Gala, which consists of both the nominations and the eviction.

One week after the season ended, an All-Stars edition - Gran Hermano: El Reencuentro premiered which featured housemates Arturo and Indhira returned to the house.

On Day 25, during Nagore's eviction, she chose Ángel to enter the main Gran Hermano house.

Initially, Ángela was simply a guest on behalf of Laura on the premiere of the eleventh season but was given the chance to become a housemate by Gran Hermano host Mercedes Milá; on Day 1, Ángela and Laura were told to keep their relationship as a secret.

She received a mixed reaction to heavy boos at the start of her eviction interview particularly due to romancing Arturo.

On Day 119, it was revealed that he and Saray will take part of a duo Housemate Exchange with the Grande Fratello house in Italy despite being nominated for eviction for the week; he did survive the eviction and celebrated in the Grande Fratello house by jumping into the pool.

Gonzalo is a male housemate from Argentina who entered on Day 1 in the main Gran Hermano house.

Indhira is a female housemate who entered on Day 1 in the main Gran Hermano house.

On Day 39, after being told she survived the fifth eviction of the season, she moved to the Spy House to decide whether Spy Housemates Carol or Carolina should become official/permanent housemates; on Day 46, she voted for Carolina to stay in the house, and Carol was evicted.

In the early hours of Day 82, Indhira had an argument with Carol (who returned to the house the previous week) which resulted in Indhira throwing a glass full of ice towards her; moments after, she became the first female ever on Gran Hermano to be ejected for aggressive behavior.

Juan is a male housemate who entered on Day 1 in the main Gran Hermano house.

Melanie is a female housemate who entered on Day 1 into the main Gran Hermano house.

Nagore is a female housemate who entered on Day 1 into the main Gran Hermano house.

In Week 3, on a group consensus, Nagore was nominated for eviction which garnered rapturous applause from the audience and heard into the house.

Pilarita is a female housemate who entered on Day 1 into the main Gran Hermano House.

Rebeca is a female housemate who entered on Day 1 into the main Gran Hermano house.

She is the daughter of fellow housemate Pilarita, who entered in the main Gran Hermano house on Day 1 as well.

Saray was told that her mother is an official contestant in Gran Hermano but must keep it a secret as she is in the Spy House.

On Day 119, it was revealed she will be going to the Grande Fratello house in Italy with Gerardo as part of a duo Housemate Exchange.

Saray is the first housemate in Gran Hermano history to never be nominated for the public vote throughout the entire season until the final week.

Siscu is a male housemate who entered on Day 1 into the main Gran Hermano house.

He was re-evicted on Day 119, making him the first housemate ever to be evicted twice via the public vote in Gran Hermano history.

In Week 5, she was nominated for eviction for the first time; on Day 39, she was told she survived the eviction and was moved into the Spy House to decide whether Spy Housemates Carol or Carolina should become official/permanent housemates; on Day 46, she voted for Carolina to stay.

On December 17, 2009 (Day 102), it was revealed by host Mercedes Milá that a housemate exchange with another Big Brother country will take place soon.

A few days later during El Debate, it was revealed Gran Hermano will exchange two housemates with ItalyGrande Fratello; the decision most likely as the television station that programs the Spanish and Italian versions of Big Brother are owned by the same company, Mediaset.

Siscu was automatically nominated by Gran Hermano (Big Brother) after bad behaviour involving Gonzalo (who was ejected).

^3 In week three: as Angel, Laura, and new housemates Carol, Carolina, and Gerardo are in the Spy House, they are immune from eviction.

In the main house, the normal nominations process was voided to stop bloc voting and alliances, and the housemates in the main Gran Hermano house had to nominate 3 people in a group consensus, meaning all housemates must agree on the potential nominees for eviction or else everyone faced eviction.

As winning the save vote against Carol on Day 46, hence earning official housemate status, Carolina gained immunity for the week.