The tag line for this edition is "La Cuarta Dimensión" (The fourth dimension).

On Day 82, five ex-housemates, Chari, Mireia, Oscar, Ruben, and Yago, returned to the Color House after an online public vote; a second round of online public voting on Day 89 decided for Ruben and Yago to officially return to the Gran Hermano house as official housemates; the other three housemates were re-evicted.

He was the seventh housemate to be evicted from Gran Hermano 12 with 82.1% of the public vote in his first nomination.

Cathaysa Mogollon is a female housemate from Venezuela who entered on Day 1 into the color house.

On Day 89, she was re-evicted after losing a second round of the online public vote to become an official housemate again.

Dámaso Angulo is a male housemate from who entered on Day 1 into the white house.

Eduardo Palomino is a male housemate who entered on Day 1 into the white house becoming the first hearing impaired person ever in Gran Hermano.

Florencia Luján is a female housemate from Argentina who entered on Day 1 into the color house.

She was ejected on Day 19 as she planned with Julio how to obtain more money outside the house and feigning a false romance.

Jose Ramón García known as Jhota is a male housemate who entered on Day 1 into the white house.

He developed a great friendship with Terry, Lydia and Patricia, which he was calling "The Jhota's girls ".

Julio Granado known as 'El Feroz' is a male housemate who entered on Day 1 into the white house.

He was ejected on Day 19 as he planned with Flor how to obtain more money outside the house and making a false romance.

She broke up with her real life boyfriend Samuel in the house to start a relationship with Marcelo.

Lydia was chosen by Gran Hermano to visit the Big Brother Israel house on 31 December 2010 as part of a housemate exchange; after 5 days, she returned to Spain.

He developed a strong friendship with Dámaso and Yago, and was part of "The Jhota's girls".

On Day 62, he temporarily left the house as part of a humanitarian trip set by Gran Hermano.

Marta López is a female housemate who entered on Day 1 into the color house.

She finally was the last person to be evicted on Day 138 with 66,1% She was a contender to win, but When the contest advanced she started losing energy and going out.

She had problems with Jhota and Terry, and she was very a friend of Mireia, Rubén, Chari and Yago.

She returned to the house on Day 82 for an opportunity to become an official housemate again; she was re-evicted the following week after losing the second round of voting.

Pepa Beltrán is a female housemate who entered on Day 33 as replacement for Flor.

She considered herself a goof strategy, but on Day 47, she was the sixth person to be evicted from Gran Hermano house with 76.4% of public votes.

Terry Willis Pérez is a female housemate who entered on Day 1 into the color house.

On Day 117 as he was the person with least nomination votes he was able to find the time capsule which meant that he was the first finalist of Gran Hermano 12 and for this reason he was immune for the last two rounds.

Shortly after Christmas 2010, it was confirmed by the Big Brother Israel website that a housemate exchange will take place with the Gran Hermano Spain house.

On 29 December, the BB Israel hosts confirmed that housemate Yaakov "Jackie" Menahem will travel to Spain in exchange with Lydia Navarro.

It was announced that the Gran Hermano Spain housemates won the contest earning top scores from all three jurors.

Gran Hermano 24 horas was a temporary television channel dedicated to the 24-hour coverage of the show.