The Gran Sasso Science Institute (GSSI) is an international school for advanced studies located in L'Aquila, Italy.

Among its founders are the academics Eugenio Coccia, appointed the first director of the institute, Paola Inverardi and Pierangelo Marcati.

The inauguration took place on 14 November 2013 in the presence of Prime Minister Enrico Letta, and the Nobel Prize in Physics Carlo Rubbia.

The institute initially operated on a trial basis as an international post graduate teaching and research institute with a special statute supported by the INFN, the University of L'Aquila, the IMT of Lucca, the International School for Advanced Studies of Trieste and the Sant'Anna School of Advanced Studies of Pisa.

[7] Each year the Gran Sasso Science Institute awards an average of 40 Ph.D. positions, 10 for each research area of the GSSI.