Granada was established as the town's second comprehensive public high school in response to significant population growth in the 1960s.

[6] The nearby Oak Knoll was previously a cemetery, before the 1906 San Francisco earthquake knocked over most of the headstones, torrential rains in 1907 washed away most of the western slope, and the site was subsequently abandoned for the next 50 years or so, until it was formally reclassified as a public park in 1963, and is now used by athletic programs.

[6] In 2023, the school removed its International Baccalaureate program, citing high cost and low student usage.

[8] After students and parents complained, questioning the district's budget numbers and interest metrics, and protesting at a board meeting, a streamlined version was reinstated.

[6] In 1992, the school changed to a block schedule with three 90-minutes classes a day, and a fourth one-hour period to meet with teachers and complete homework.