It evolved from the earlier office of the domestic of the Schools, and came to rank as one of the senior dignities in the Byzantine state during the last centuries of its existence.
[5] In the Palaiologan period (1261–1453), the grand domestic was the unchallenged commander-in-chief of the army, except in the case of the emperor campaigning in person, when he functioned as a kind of chief of staff.
[6] Despite its purely military nature, the office was also bestowed in the way of an honorific dignity to generals and high-ranking courtiers alike, e.g. to George Mouzalon, or to the Prince of Achaea William II of Villehardouin.
In the 13th century, it rose and fell according to the emperors' desire to honour its holder, but was usually at seventh place, below the prōtovestiarios and the megas stratopedarchēs.
[7] At all times, however, it was regarded as one of the most important and prestigious positions, and was held either by members of the reigning dynasty or by close relatives from the small circle of families connected to the imperial clan.