The region headquarters are in Capellen, Diekirch, Esch-sur-Alzette, Grevenmacher, Luxembourg City, and Mersch.

Local police stations (Commissariat de Proximité, abbreviated 'CP') operate separately from the CISs and CIPs, but are under the control of the regional director.

In addition to the thirteen CIPs and CISs, which perform the role of CPs, there are thirty-eight dedicated local stations, distributed across the main towns and cities of Luxembourg.

A special police division at Luxembourg – Findel Airport is directly responsible for border control.

Officers are armed with the Heckler & Koch VP9 (SFP9 model in use) chambered in 9×19mm Helperknapp, Larochette, Lintgen, Lorentzweiler, Mersch, Nommern, Steinsel The head of the Grand Ducal Police is the Director-General.