The line built by the company, which opened in 1837, linked the Liverpool and Manchester Railway to Birmingham via Warrington, Crewe, Stafford and Wolverhampton.

The company merged with its business partners in 1846 to form the London and North Western Railway (LNWR).

[4] It began operation with a temporary Birmingham terminus at Vauxhall,[5]: 12  The travelling post office where mail was sorted on a moving train was instituted on the Grand Junction Railway in January 1838.

Using a converted horse-box, it was carried out at the suggestion of Frederick Karstadt, a General Post Office surveyor.

The route between Curzon Street railway station and Vauxhall primarily consisted of the Birmingham Viaduct.