On September 15, 1808, the Grand Lodge of Pennsylvania granted a warrant to Meriwether Lewis (leader of the Lewis and Clark Expedition, and the first governor of the Territory of Louisiana), Master, Thomas Fiveash Riddick, Senior Warden, and Rufus Easton, Junior Warden, for Saint Louis Lodge No.

By act of the General Assembly approved February 13, 1864, certain named members of the"Grand Lodge of the State of Missouri of Free and Accepted Ancient Masons were incorporated as "The Grand Lodge of the State of Missouri of Free and Accepted Ancient Masons."

By act of the General Assembly approved March 22, 1870, the Grand Lodge of Ancient, Free and Accepted Masons of the State of Missouri was, among other things, "authorized to own property of any value not exceeding $300,000.00."

[1][2] The Grand Lodge operated Masonic College in Lexington, Missouri during the middle part of the 19th century.

President Harry Truman was a prominent Missouri mason; his apron is on display at the Grand Lodge.

Author Mark Twain was affiliated with Polar Star Lodge Number 79 in St. Louis Missouri.