The Grand Pacific Hotel is a historic Victorian era building located at 366 5th Avenue in the Gaslamp Quarter of San Diego, California.

It was run as a hotel and in 1901 it became the home of the Helping Hand Mission.

The building remained a hotel onder various names and management until May 1960.

In the mid- 70s, the Grand Pacific became a contributing building to the rebirth of the Gaslamp Quarter Historic District and is on the National Register of Historic Places.

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