Grand Prix Cycliste La Marseillaise, formerly known as the Grand Prix d'Ouverture La Marseillaise, is a single-day road bicycle race held annually in February around the city of Marseille, France.

Since 2005, the race is organized as a 1.1 event on the UCI Europe Tour.

It is usually the first race of the European calendar, one day before the stage-race Étoile de Bessèges, which is held in the same region.