Grande-Rivière (French pronunciation: [ɡʁɑ̃d ʁivjɛʁ], literally Great River) is a city in the Gaspésie-Îles-de-la-Madeleine region of the province of Québec in Canada.

In addition to Grande-Rivière itself at the mouth of the namesake Grand River [fr], the town's territory also includes the communities of Grande-Rivière-Ouest, Petite-Rivière-Ouest, and Petit Pabos.

[5] In 1697, Jacques Cochu was granted the seignory of Grande-Rivière, named after the namesake river that drains there into the Gulf of St. Lawrence.

By the middle of the 18th-century, about 70 families were living there, but in 1758, the place was destroyed by General Wolfe's army during the Gulf of St. Lawrence campaign.

[1][5] By 1795, the seignory was owned by Charles Robin, whose company established fishery operations in Grande-Rivière, opening a fish processing plant in 1828.