The Baltimore and Ohio Railroad (B&O) announced plans for it on May 3, 1955, after selling the original B&O Station bordering the Monongahela River to the state for construction of Interstate 376.

However during the late 1950s the B&O ran a two-car (RDC'S) inter-city train to/from Washington DC.

Grant Street was the last such privately owned train station built in Pennsylvania.

[1] After the Port Authority of Allegheny County (PAT) assumed control of the B&O's Pittsburgh—McKeesport—Versailles commuter route in 1975 (which it re-branded PATrain), Grant Street continued to serve as the Pittsburgh depot for this service.

The site is now home to PNC Firstside Complex and the First Avenue light rail station.