Grants Pass High School was originally built in 1885, in a wooden building located at Fourth and C Streets.

Teams include football, cross country, volleyball, equestrian, swimming, skiing, basketball, wrestling, soccer, bowling, baseball, golf, softball and tennis.

In December 1948, the Cavemen won the state football championship after defeating Jefferson High School 6-0.

During the return trip, the chartered bus transporting the team went off the side of the road, resulting in the deaths of two athletes: Sterling Heater and Al Newman.

Roughly 700 athletes from at least 30 schools across Oregon and Northern California compete in the event annually.

[10] Grants Pass High School offers many extracurricular clubs and programs, including Academic Masters, Brain Bowl, Choir, Leadership, Marching Band and Color Guard, Math Team, Music Honor Society, Mock Trial, National Honor Society, Orchestra, Skills USA, State of Jefferson Scavenger Hunt, and Theatre.

[19] The school's Brain Bowl team has held the title of Division A champions for two consecutive years.

[21] The school's marching band was named the 2010 NWAPA circuit champions for their production "Traffic".

[22] The Marching Band and Auxiliary performed in the 2010 Macy's Thanksgiving Day Parade by invitation on November 25, 2010.

On November 16, 2021, a student-lead walkout against the decision by the school district to reinstate Rachel Damiano and Katie Medart occurred.