Grantville Gazette II is the third collaborative anthology published in print set in the 1632-verse shared universe in what is best regarded as a canonical sub-series of the popular alternate history that began with the February 2000 publication of the hardcover novel 1632 by author-historian Eric Flint.

Composer Giacomo Carissimi is directed by Cardinal Mazarini (Mazarin) to visit Grantville, and finally obtains adequate funds.

Eventually, with guidance from his wife, Schultheiss changed his stance on Grantville and becomes more tolerant of the Americans' ideals, including freedom of religion.

It deals with public health and integration and dissemination of medical knowledge efforts during the end of the Confederated Principalities of Europe and early United States of Europe period, for the various Mike Stearns-led administration's have been repeatedly reminded by Dr. James Nichols and Melissa Mailey how vulnerable populations are and were to diseases in the seventeenth century era—so the up-timers have been both strategically aware and taking steps from the outset within their capabilities and resources to mitigate any preventable health problems beginning in the novel 1632.

The story is one of Grantville's medical personnel meeting head-on with down-timer University practices, prejudices and a college curricula based in large part on the Classics and Theological studies.