Graphis desquamescens is a species of script lichen in the family Graphidaceae.

[2] It has a broad distribution and can be found in various countries including Brazil, Dominica,[3] the United States,[4] Mexico, and Japan.

It also occurs in different parts of Australia such as Queensland, New South Wales, Victoria, and Tasmania.

[5] There has been little agreement in the literature as to the length of the ascospores in this species; they have been given various ranges extending from 18 μm to as high as 50 μm; the ascospores of the lectotype specimen have a reported range of 25–35 μm.

[4] The novel pigment named graphisquinone was isolated from cultures of the spore-derived mycobionts of this lichen.