Gray Matter is a point-and-click adventure game designed by Jane Jensen, creator of the Sierra Entertainment Gabriel Knight series.

It follows the story of Samantha Everett, a street performer and magician, and Professor David Styles, an acclaimed and mysterious neurobiologist.

The opening scene of the game depicts Sam riding her motorcycle in the rain in the countryside while traveling to London, and accidentally being redirected to Oxford because of a broken street sign.

Her bike breaks down, forcing her to take shelter in Dread Hill, a nearby mansion where David resides.

The professor recalls her to Dread Hill, letting her know that he found a fifth candidate and making Sam herself the sixth.

As the game progresses, Sam learns about the professor's past, his research on the paranormal, the prestigious members-only Daedalus magic club, a series of bizarre events that take place at Oxford University, and how these elements are connected.

Club praised the puzzles and writing of the PC version and called it "the best traditional adventure game in a decade".