Grayson is a village in Caldwell Parish, Louisiana, United States.

According to the United States Census Bureau, Grayson has a total area of 1.3 square miles (3.3 km2), all land.

[3] Though primarily associated with Columbia, former Governor John J. McKeithen was born in Grayson in 1918.

The Louisiana historian Hubert D. Humphreys was born and reared in Grayson.

He published an article on the village in a 1992 edition of the journal, North Louisiana History.