Grdelica (Serbian Cyrillic: Грделица) is a town in southern Serbia.

It lies at an important transport route, on the main road and railway corridor linking Serbia with Macedonia and Greece.

In 2016., the section around Grdelica was the last part of the A1 motorway to be completed to a full dual carriageway profile.

Woodworks "Danilo Bošković" and "Textile Industry Grdelica (TIG)" are two major factories.

It was part of an Iron Age culture, with 8th-century-BC pottery found in the downstream river.