Robert Merydale was parson of the parish church of Great Brickhill in 1470, according to a legal record, in which Edward Lucy & Thomas Hampden claim that he owed them £20.

That Great Brickhill survives today as a village is due in no small part to the objections of its residents to the ever-increasing development of Milton Keynes.

The high brick wall, reminiscent of that at nearby Woburn, which runs for some distance adjacent to the road, now neglected and ruined in places, surrounds the 70-acre (280,000 m2) park which once housed the principal seat of the Duncombe family, Great Brickhill Manor.

The last manor house to occupy this park was built circa 1835, a large square brick stuccoed building of no particular architectural merit – old photographs show a slight Italianate influence in the design, a style later made popular by Queen Victoria at Osborne House.

The Duncombe family (the head of whom since 1859 has been a Baronet) continue to live in the village and own the estate; however, they now reside at what used to be the old Rectory near the church.

The parish church of St. Mary the Virgin is a Grade II* listed building, dating back to the 13th century.