The show features lists and biographies of influential persons, who came to prominence in their fields throughout the history of Greece, in order to be determined through a voting procedure who is considered the greatest Greek of all time by the audience of Greece.

The first part consisted of a voting procedure, which began on 16 April 2008 and lasted until 7 May 2008, in order to choose the 100 predominant personalities.

The second part launched with a couple of two-hour-long episodes, which presented the top 100 and revealed the 10 nominees.

The third part, the Great Final, took place on 18 May 2009, hosted by Alexis Papahelas.

It was a live debate between the ten celebrity supporters of the previous episodes and twenty-five advocates, until the end of the voting and the announcement of the Greatest Greek.