The Great Lakes Science Center is a museum and educational facility in downtown Cleveland, Ohio, United States.

Opening in July 1996, the facility includes signature (permanent) and traveling exhibits, meeting space, a cafe, and the Cleveland Clinic Dome Theater.

In February 2024, the Science Center opened the Cleveland Creates Gallery, a new permanent exhibit focused on the Northeast Ohio's contributions to manufacturing technology.

Interactive exhibits in the gallery highlight technological advances in the fields of aeronautics, robotics, steel and chemistry developed locally "meant to inspire the next generation of innovators to pursue STEM careers in Cleveland."

The flagship has huge cargo holds, brass and oak pilot house, guest quarters, and four-story engine room.

School is in session year-round, with students working for 10 weeks, taking a three-week break and then repeating that pattern for four 10-week terms throughout the year.

The Alliance creates conversations and connections to bring attention to these critical issues and develop an economy in Northeast Ohio around their solutions.