The Great Midwest Conference was an NCAA Division I athletics conference that existed from 1991 to 1995.

It was formed in 1990 with six members: Cincinnati and Memphis State (now Memphis) from the Metro Conference, UAB from the Sun Belt Conference, Marquette and Saint Louis from the Midwestern Collegiate Conference (now the Horizon League), and independent DePaul.

Cleveland State and Detroit-Mercy had some interest from coaches, while Louisville and Tulane were heavily favored by athletic directors.

[2] In 1995, six of the schools in the Great Midwest (except for Dayton, who joined the Atlantic 10 Conference) joined with UNC Charlotte, Louisville, Southern Mississippi, Tulane, and South Florida of the Metro and Houston of the dissolving Southwest Conference and formed Conference USA.

The following were the locations of the GMC men's basketball tournament.