Great Missenden is a village and civil parish in the Misbourne Valley in the Chiltern Hills in Buckinghamshire, England, situated between the towns of Amersham and Wendover.

[2] The source of the Misbourne is to be found just north of the village, although the upper reach of the river runs only in winter and the perennial head is in Little Missenden.

Several coaching inns, particularly the Red Lion (now an estate agency) and The George (with new owners), provided rest and refreshment for travellers and their horses.

Gipsy House in Great Missenden was the home of author Roald Dahl from 1954 until his death in 1990, and still remains in the family,[3] and many local scenes and characters are reflected in his work.

[citation needed] Dahl is buried at St. Peter and St. Paul's Church and children still leave toys and flowers at his grave.

[11] Robert Louis Stevenson, the writer of famous works such as Treasure Island and the Strange Case of Dr Jekyll and Mr Hyde, stayed a night at The Red Lion, now 62 High Street, in Great Missenden in October 1874, which he wrote in an essay called "An Autumn Effect".

The espionage novelist David Cornwell, who wrote as John le Carré, noted in a posthumously published introduction to a 2021 reissue of his first novel, Call for the Dead, that "I lived in Great Missenden in those days and commuted to Marylebone station".

Of note is the episode "Rude Awakening" starring Denholm Elliott who plays an Estate Agent trapped in a recurring nightmare.

The industry of employment of residents was 13.3% retail, 11.6% manufacturing, 5.5% construction, 24.1% real estate, 9.7% health and social work, 8.8% education, 4.7% transport and communications, 3.6% public administration, 4.2% hotels and restaurants, 4.3% finance, 1.9% agriculture and 8.3% other.