Great Oxendon is a linear village and civil parish in West Northamptonshire in England.

The former railway tunnel at Great Oxendon is now open as part of the Brampton Valley Way.

Between 1859 and 1960 the village was served by Clipston and Oxendon railway station about one mile south-east of the village and with running trains between Northampton in the south and Market Harborough in the north.

Little Oxendon is a deserted medieval village about one mile north of Great Oxendon at grid reference SP730846.

The Historic England website contains details of a total of four listed buildings in the parish of Great Oxendon, all of which are Grade II apart from St Helen's Church, which is Grade II*.