The Great Synagogue of Petah Tikva (Hebrew: בית הכנסת הגדול בפתח תקוה) is an Orthodox Jewish congregation and synagogue, located on Hovevei Zion Street, in the centre of Petah Tikva, in the Central District of Israel.

Completed in 1900, the building was designed by Daniel HaCohen Lifshitz, and is one of the pioneering residents of the city, and was named Beit Yaacov Synagogue, in honour of James Mayer de Rothschild, the father of the Baron Edmond James de Rothschild.

Construction of the Great Synagogue of Petah Tikva began in 1885 with a contribution from the Hovevei Zion movement.

[1] Edmond James de Rothschild donated the money needed to complete the building, which was named Beit Yaacov in honor of his father.

In the late 2000s, the synagogue was the target of vandals who spray-painted swastikas and other Nazi-themed words on the building and inside on multiple events.