Greatest Hits: The Road Less Traveled is a compilation album by American singer-songwriter Melissa Etheridge, released by Island Records on October 18, 2005.

AllMusic rated the album 4+1⁄2 out of 5 stars, and stated "Greatest Hits: The Road Less Traveled is a comprehensive, entertaining, and ultimately redemptive collection from a woman who truly deserves it."

Also released for radio was the new song "I Run for Life", written about her struggle with breast cancer.

The album was certified Gold in December 2005, for sales of over 500,000 copies.

[2] All songs by Melissa Etheridge, except where noted Singles – Billboard (United States) [6] ^ Shipments figures based on certification alone.