Greatest Hits is the first compilation album released by American singer Melissa Manchester.

The compilation spans 10 songs, which cover the years 1975 to 1983, starting with Manchester's first Arista single (and first top 10 hit) "Midnight Blue", from her third album Melissa up to two new songs recorded specifically for this record: "Nice Girls" and a medley of two 60's covers: "My Boyfriend's Back" and "Runaway", both produced by Arif Mardin, who had produced Manchester's previous record Hey Ricky.

In addition, "Come In From The Rain", a song which Manchester wrote and first recorded in 1976 as an album track but became a hit for Captain & Tennille a year later, is also included, albeit in its 1982 remixed version found on Manchester's album Hey Ricky.

"Nice Girls" and "My Boyfriend's Back" were released as singles, with the former peaking at #42 in the Billboard Hot 100.

The compilation peaked at #43 in the USA, and was a steady seller, eventually being certified gold in 1989 by the RIAA.