[1] Previously, in 1994, the singer released her first compilation of hits entitled Los Deseos De Thalia (Grandes Exitos) which included tracks from her first three albums: Thalía, Mundo de Cristal and Love, the collection was promoted on TV through commercials and ended Thalía's contract with Fonovisa.

It also includes the theme of Thalía's soap opera María la del Barrio and plus two previously unreleased songs "Acción y Reacción" and "Cuando Tu Me Tocas".

The album was released in three formats: a Walmart's exclusive CD + DVD which includes 10 tracks plus 10 music videos and multimedia gallery, a standard CD with 16 tracks and DVD that features a grand total of sixteen videos, such as "Gracias a Dios", "Amor a la Mexicana", "Entre el Mar y una Estrella", "Tú y Yo", and "¿A Quién le Importa?".

The music video contains footage from Thalía's "High Voltage Tour" in the United States and Mexico.

Jason Birchmeier from AllMusic website wrote that the album is "a well-balanced sample of the Latin pop star's many hits from the mid-'90s to the early 2000s" and "a great beginning-to-end listen -- again, a nonstop pleasure as the joyful, feel-good parade of hits cascades over the course of the hour-plus CD."

In his review for DVD Movie Guide Colin Jacobson wrote that "despite some misfires, Thalia's Greatest Hits offers a pretty nice collection" and that "the package still tosses in a lot of solid stuff, and the videos mostly work well".

[11] In Thalía's home country, Mexico, both the album and the DVD release, were certified with Gold by AMPROFON.

[12][13][14] In Argentina, the DVD received a Platinum certification from the Argentine Chamber of Phonograms and Videograms Producers.