Greek-Dutch singer Stefania was internally selected by the Hellenic Broadcasting Corporation (ERT) to represent the nation with the song "Last Dance", written by Dimitris Kontopoulos, Arcade, and Sharon Vaughn.

To promote the entry, a music video for the song was released and Stefania made appearances on Greek television and in print media.

In the 2018 contest, Greece failed to qualify for the second time with Yianna Terzi and the song "Oniro mou" finishing 14th in the semi-final.

On 18 March 2020, the day of the 2020 contest's cancellation, ERT was one of the first four broadcasters to confirm their participation in the next edition and to announce their continued cooperation with their 2020 artist, Stefania.

[11] With ERT opting to continue their cooperation with 2020 artist Stefania for 2021, it was announced that the same team responsible for the songwriting and the choreography of the 2020 entry would also be used for the 2021 contest, and that the song would be selected internally.

[13] Songwriters Dimitris Kontopoulos, the production team Arcade and Sharon Vaughn,[14] submitted at least four potential entries to ERT for consideration.

[22] Stefania was also interviewed by Greece's celebrity magazine Gala alongside her uncle, actor Yannis Stankoglou,[23] and was featured in a photoshoot in Hello!

[31] The performance featured Stefania in purple amongst a green screen which removed the bodies of her four dancers leaving them as empty white suits, an arrangement which created a marked difference between what television and online viewers saw versus the limited live audience.

[32] The dancers included George Papadopoulos (stage director for the Greek entry at the 2014 Contest),[33] Nikos Koukakis, Markos Giakoumoglou and Costas Pavlopoulos.

[37] Soon after, the EBU posted the running order for the final, placing Greece in position 10, following United Kingdom and preceding Switzerland.

[41][42] Greece's jury consisted of Adam Tsarouchis, Athena Konstantinou, Fotis Sergoulopoulos, Ioannis Vasilopoulos, and Xenia Ghali.

Over the course of the contest, Greece awarded both sets of 12 points from its jury and televote respectively to Moldova in the second semi-final and to Cyprus in the final.

At 10 years old, the actor from the ERT series Ta kalytera mas chronia became the youngest spokesperson in contest history to this point.