Greektown is a commercial and entertainment district in Detroit, Michigan, located just northeast of the heart of downtown, along Monroe Avenue between Brush and St. Antoine streets.

Notable buildings include Annunciation Greek Orthodox Cathedral, St. Mary Roman Catholic Church (originally built for the former ethnic German congregation of the parish), Second Baptist Church, the Atheneum Suite Hotel, and the contemporary Hollywood Casino at Greektown (formerly Trapper's Alley, opened in 1972 by Frances and David Sonne) within its boundaries.

[3] However, in the earliest years of the 20th century, most of the ethnic German residents, who had gotten established in the city, began moving from the neighborhood into newer residential areas farther from downtown.

Certain buildings on Monroe Street feature themes related to the mythical Pegasus, and such historic Greek structures as the Parthenon, and other ancient architecture.

In the American cable TV series Low Winter Sun (2013), the Detroit Police precinct is located four blocks from Greektown.

Seeking to gain independence from Skelos, Damon opens a blind pig outside of Greektown, where he kicks up to Reverend Lowdown (season 1, episodes 3 and 4).