The Green Plain Monthly Meetinghouse is a historic former Quaker house of worship near South Charleston in Clark County, Ohio, United States.

The original Green Plain Monthly Meeting lasted for only a short while, splitting into Orthodox and Hicksite branches just four years after it was founded: the Orthodox members settled in the community of Selma, while the Hicksites kept the original property.

In turn, the Hicksites split in 1843 over the issue of slavery; the liberal party kept the original church, while the conservatives moved to South Charleston-Clifton Road and built the present building.

It qualified because of its historically significant architecture:[1] few so well-preserved and little-changed Quaker meetinghouses remain in this region of Ohio, so it permits a nearly unparalleled view of the lives of some early Ohioans.

[2] Included in the historic designation was the monthly meeting's cemetery,[1] which has stones with death dates as far back as 1843.