Greenfield is a city in Greene County, Illinois, United States.

Carrollton, the Greene County seat, is 13 miles (21 km) to the southwest via Routes 267 and 108.

There were 489 housing units at an average density of 275.18 per square mile (106.25/km2).

27.77% of all households were made up of individuals, and 21.50% had someone living alone who was 65 years of age or older.

Greenfield CUSD 10 serves portions of Greene, Jersey, Macoupin and Morgan Counties.