The 15-hectare (37-acre) mixed commercial and residential complex is in the crossroads of EDSA and Shaw Boulevard immediately south of the Ortigas Center financial district.

[1][2][3] Greenfield District is situated along Metro Manila's main thoroughfare, EDSA, near the geographic center of the metropolis.

Greenfield District is on a 30-hectare (74-acre) plot of land acquired by Unilab founder Jose Yao Campos from Ortigas & Company in the 1950s.

For a long time, the area belonged to the 4,033-hectare (9,970-acre) Hacienda de Mandaloyon (also known as Mandaloya, Mandaloyen, or Mandaloyong), a former friar estate owned by the Order of Saint Augustine which Francisco Ortigas purchased in the 1920s.

[8] It launched its first condominium project in the district in January 2004, the Soho Central, in partnership with Jose Antonio's Meridien Development Group.

[9] In March 2007, Unilab announced that it would be transferring all its production facilities in Mandaluyong to its 35,000-square-meter (380,000 sq ft) Pharma Campus in Biñan, Laguna.

[1][3] Other notable establishments in the District include the offices of Greenfield Development Corporation, a Bank of the Philippine Islands branch, and the open-air Mayflower Parking that houses the Food Truck Fest, fire and police sub-stations, a Maxus showroom, Unilab's main and R&D offices, and warehouses respectively belonging to La Perla and Univet Nutrition and Animal Healthcare Company (UNAHCO).