Two places that are separately listed on the National Register, the Westmoreland County Courthouse and the Greensburg Railroad Station, are included in the district.

Not only was it an important station on the Pennsylvania Railroad, but it was also the headquarters of West Penn Railways, an interurban (long-distance trolley) company serving many small communities to the east and south of Greensburg.

The headquarters building of West Penn Railways is still extant at 416 South Main Street, serving as City Hall, although it is outside the boundaries of the historic district.

The opening of Greengate Mall in 1965 (now demolished) had a devastating impact on downtown retailing, following the pattern that occurred in numerous communities.

[8]In order from north to south:This street was named after Ludwig (or Ludwick) Otterman (originally Ottoman) (1738–1791), an early settler.